Reduced loads, Managed recoil, Youth loads etc - this topic seems to come up reasonably regularly. There have been some quite different approaches to achieving reduced loads, but here is one direct from a manufacturer that is presumably tested, safe in all cases and requires no stuffing around with filler etc.
Hodgdon recommend using H4895 - I emailed ADI and this powder
is 2206H (I will paste in their email below)
If H4895 (or 2206H) is listed for a load then multiply the max load by 0.6 (60% of max) The Hodgdon data sheet is here
http://www.hodgdon.com/PDF/Youth%20Loads.pdf Note the data is from Hodgdon & I have personally made the stretch to include ADI data - make your own decision please.
You can adjust up or down by another 10%. It says nothing about fillers and states that the powder ignites uniformly at reduced loads. (I recon a little filler dosent hurt

)
I am currently using this to keep my .243 cranking a little longer - a new Mannlicher barrel is going to be $1500+

Same would apply to 22.250 shooters or any overbore cartridge - they dont need to be going full speed to smoke vermin or at the range.
Good luck - please post up any results or comments
Text from ADI email:Thankyou for your recent enquiry with regard to reloading using ADI Sporting powders.
Some ADI propellants are sold in the US by the Hodgdon Powder Company, including AR2206H which is sold as H4895. It is the same powder.
Extreme caution should be taken and loads should be worked up accordingly. Refer to our website at
www.adi-limited.com/handloaders-guide or our handloaders’ guide for more information, warnings and reloading safety.
We thankyou for using ADI Sporting Powders